Looks great man.
I don't use the SATA 3's - AFAIK
they're actually slower than the ICH. I use the USB 3's, but don't own any USB 3 devices. Windows 10's drivers seem to have taken care of most things, but I always install Energy Saver to use the ?LLC control? it enables. I leave LLC off in BIOS, but run Energy Saver in background as it slightly reduced the Vdroop, the same as it did on the UD3 before it. I think I also installed the latest chipset driver... though exactly wherefrom - I forget.
Are you planning on SLI? I had to use a PCIE extender to get enough physical separation between my cards if I used the best slots.
Here's my layout, it seems to cool the chipset and VRM's OK. The casefans are not especially powerful, but their proximity (and the Zalman) seem to keep everything chilled.
Case tipped on front here, and I didn't keep the DIY shroud either. The side panel has a few slats, so it draws cold air in right over the CPU and some over the GPUs too. Runs cooler closed!