4x1GB puts more stress on the memory controller, which is rumored to have some negative effects on overclocking. However, I have heard that this was more of a problem with socket 939, and that socket AM2 doesn't struggle anymore with 4x1GB than it does with 2x2GB.
4x1GB makes it more expensive to upgrade to 8GB in the future, but that's not a big deal. By the time you need/want 8GB, you'll probably be looking at DDR3 anyway. However, 4x1GB also increases the chances of memory dying, as you have 4 sticks that need to stay healthy versus 2 sticks.
Honestly I don't think it's a big deal either way. Those G.Skill 2x2GB PC2 8000's are good for that price, but so are the 4x1GB Patriot's. I bet they'd both overclock about the same, I say flip a coin. The first set of G.SKill you linked to aren't very good though, don't choose those if you decide to go 4x1GB.
And remember, both Windows 32-bit and 64-bit have the memory hole between 3-4GB. You can get around that with 64-bit Windows by enabling memory hole remapping, but that can be a little buggy with some motherboards.
Quote: Originally Posted by CyberDruid
I want it pink inside and out...