[Ars] Drug restores cells that are missing in MS patients - Overclock.net

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post #1 of 10 Old 10-14-2013, 03:58 PM - Thread Starter
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Originally Posted by Diana Gitig 
One of the most effective inducers of OPC maturation they found is a drug called benztropine, which is already available in oral form as an approved treatment for Parkinson’s disease. Once the researchers homed in on benztropine, they confirmed that the oligodendrocytes it had coaxed into maturity could in fact make myelin when in a dish with neurons. The team then analyzed benztropine’s activity in a mouse model of MS, finding that it diminished the clinical severity of the acute and remission phases of the disease while pretty much eliminating the relapse phase. In this model system, benztropine worked at least as well as the immunosuppressive drugs now in use to treat MS.

Benztropine isn't ideal. Its use is “associated with dose-dependent adverse neurological side effects”—cognitive changes, blurred vision, anorexia, and psychosis. So the authors decided to see if it could be used at a lower dose when combined with other therapies.

Drug restores cells that are missing in MS patients


Too bad it's only in the animal studies stages, hopefully it reaches human trials and displays similar effectivity there. Don't have MS myself, but I hope this research helps those who do around here. As it is, I'm a geneticists and I'd prefer to find a permanent genetic therapy solution instead.

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post #2 of 10 Old 10-14-2013, 04:51 PM
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Hope it works well for people. smile.gif
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post #3 of 10 Old 10-14-2013, 05:04 PM
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I've lost an aunt to MS, another aunt has limited mobility due to it (ended her law enforcement career), and another acquaintance in the early stages. This looks promising but as stated, hopefully it continues this trend into human testing. thumb.gif

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post #4 of 10 Old 10-14-2013, 05:23 PM
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Originally Posted by tubers View Post

Hope it works well for people. :)
This... Interesting findings

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post #5 of 10 Old 10-14-2013, 05:52 PM
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Originally Posted by Angrybutcher View Post

I've lost an aunt to MS, another aunt has limited mobility due to it (ended her law enforcement career), and another acquaintance in the early stages. This looks promising but as stated, hopefully it continues this trend into human testing. thumb.gif

You should probably get tested if you haven't already since MS clearly runs in your family

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post #6 of 10 Old 10-15-2013, 06:35 PM
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Originally Posted by serp777 View Post

You should probably get tested if you haven't already since MS clearly runs in your family
Neither were blood relation. Uncle's original wife several years ago. Step-dad's sister.

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post #7 of 10 Old 10-15-2013, 07:59 PM
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I would love to see a cure for MS.We used to rent the apt to a woman with MS..she went downhill..
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post #8 of 10 Old 10-15-2013, 08:11 PM
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Hmm, interesting. I'll have to keep an eye on this as my mother has had progressive MS for many years and is continually doing worse. Who knows how long it could take to get this stuff to market...
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post #9 of 10 Old 10-15-2013, 11:05 PM
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Being 20 and a MS patient for a little over a year now, I can definitely say I am glad research seems to be paying off.

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post #10 of 10 Old 10-15-2013, 11:37 PM
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It's so cool you linked this. My friend, who is in research, is doing the exact same thing at the Baylor College of Medicine and recently got published in his first year (no small feat, by any means). He told me about his experiments with a drug that was able to stop the damage done by diseases such as MS and other simliar ones.

He did the testing in mice, and in almost all the cases, the drug stopped the damage, and in some, the damage was even reversed! It's still quite a ways away from a human form of the drug, but it's still very cool to see what he was telling me about on paper.
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