The NZXT 410 should house the H100i just fine. As for the vid card, I've Nvidia biased these days so I'll let someone else handle that question. Edit: I bought my Dad a 410 for christams and upon Eyeing the case when we put all his parts in I considered an H100 for him. the clearance shouldn't be a problem. I'm sure I could find someone on OCN with a 410 and H100.