The second fan made the front panel and 24pin cables a tight fit.
GPU/Radiator clearance. You only have about 195mm if you are using the radiator side ways and want to keep the drive bay. A antec 620/ corsair h60 will allow cards like the 7850 to fit.
Don't think i'll have the time to do benches anytime soon, but my temps are:
GPU: 7850 (maxed oc in afterburner 1050/1450)
CPU (4.5ghz) :