I suppose you can drown anything out with enough noise. I have a couple of Corsair SP 120 fans on a 240 rad and they're anything but quite. The XSPC fans that were on there were more quite. Anyway Good Luck with your system.
Of what your CPU. your CPU Cash , or your GPU stuff? LLC might help a little. I don't know, I am new to ASUS MB's myself and have the Hero 7. So I'm learning this stuff but those were the only places I noticed an adaptive setting associated with them. G/L