Pros: Excellent cooling and voltage tweaking functions.
Cons: 3-slot-design may eat up too many PCI slots for some.
For those considering sticking to a single-GPU solution there's really no need to look any further, this is hands-down the best air-cooled GTX580 out there, rivaled only by MSI's Twin Frozr 580 - which is almost always more expensive than Asus's equivalent.
Two 2x8-pin power connectors, 2xDVI, 1xHDMI, 1xDisplayport and voltage tweaking offering up to 1.25v (can be unlocked further) are some of the many features available.
For those into asthetics, this GPU also comes with a very sexy backplate! Something which most brands fail to include.
Now I mention single-GPU solutions because one massive con for this card is it's triple-slot profile. This can limit SLI capability on some motherboards, if you're having two of these running the top one will almost be completely smothered by the bottom one. Tri-SLI or Quad-SLI capability could be extremely limited - again, depends on motherboard.
So basically the size is the only con, it may also sag a bit due to sheer weight so (if you want) you can prop it up with something.
Hope my shoddy attempt at a review helped