Why would someone want this? As in, it is ~$400, not to mention you can't even SLI it with another one. If you were going to buy this, why wouldn't you just buy a GTX 580? Lower power consumption, and close to the performance of the 460 2WIN without all the SLI problems. You could also just go with the world renown XFire 6950s, for $100 more and get almost double the performance?
Why couldn't they make something more reasonable if they had to do this, like maybe a dual 470 card, or just an OC'd 580 (for the noobs that can't overclock their GPUs)? It doesn't make sense to me, people are hating on Fermi for high heat and power consumption, so what is this gonna solve? Even a watercooled GTX 480 could match this thing's performance.
I guess my conclusion is, although this card sounds and looks cool, I don't think it's realistic.
EDIT: Wow I forgot the biggest point, if you need 460s, you could by 3 or 4 of them for this price and SLI those. That's twice the performance for the same price.