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[Ars] Unnatural amino acids combine with HGH to make for better therapy

post #1 of 5
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The universal genetic code allows for 20 amino acids to be used in proteins. They can be smaller, bigger, acidic, basic, polar, nonpolar, linear, or with rings—but there are only 20. Of course there are plenty of other amino acids that can be synthesized, but DNA cannot instruct cells to put them into proteins.
I couldn't really find anything I thought would be interesting to quote.
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Trinity
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post #2 of 5
Just use this: (Actually found it very interesting)

Quote:
The universal genetic code allows for 20 amino acids to be used in proteins. They can be smaller, bigger, acidic, basic, polar, nonpolar, linear, or with rings—but there are only 20. Of course there are plenty of other amino acids that can be synthesized, but DNA cannot instruct cells to put them into proteins.

Or at least it couldn’t until 2001, when researchers at The Scripps Institute in La Jolla published a paper, entitled "Expanding the genetic code of Escherishia coli," in Science. They described the creation of a unique tRNA/aminoacyl-tRNA synthetase enzyme pair that incorporated a synthetic amino acid into proteins in bacteria. Similar feats have since been accomplished in eukaryotic and mammalian cells, and a new report in PNAS uses the technique to make a modified protein with clinical relevance: human growth hormone (hGH).
The quotes aren't really for interesting stuff alone, but also to see if it's something you would like to read further, so the first portion is usually the answer.
Edited by Madman340 - 5/22/11 at 5:49pm
post #3 of 5
Essentially increases the biological t1/2. Just a better way to PEGylate drugs. Pretty neat, of course it will take time for that to be approved for humans (unless there was already work done on that, not sure about that), similar to other excipients.

Hopefully this thread isn't closed either.
post #4 of 5
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Originally Posted by HybridCore View Post
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I couldn't really find anything I thought would be interesting to quote.
But you found the article interesting to post here?
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Quote:
Originally Posted by Shadowclock View Post
But you found the article interesting to post here?
That's what I was thinking
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