Originally Posted by justarealguy
You've posted this twice now. Care to explain your reasoning? Less DIMMs is less work on the IMC, which generally means lower volts / higher clocks.
The only reason I would see is that a 4GB module will overclock less than an 2GB module. Apart from that, 4GB modules can still clock quite high, so I'd get 2x4GB over 4x2GB.