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[CBS San Francisco] Apparent Immunity Gene ‘Cures’ Bay Area Man Of AIDS  

post #1 of 25
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Quote:
SAN FRANCISCO (CBS 5) — A 45-year-old man now living in the Bay Area may be the first person ever cured of the deadly disease AIDS, the result of the discovery of an apparent HIV immunity gene. Timothy Ray Brown tested positive for HIV back in 1995, but has now entered scientific journals as the first man in world history to have that HIV virus completely eliminated from his body in what doctors call a “functional cure.â€

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post #2 of 25
This story has been reposted several times and is rather old news. I gave a presentation on this 3 years ago in my PhD level Immunology class.

In a nutshell the cure works like this:
1. HIV infects T cells
2. T cell precursor cells are created in your bone marrow
3. HIV requires certain receptor proteins to be on the T cells in order to infect them.
4. Doctors find suitable bone marrow donors that are mutant for those receptors.
5. Doctors transplant mutant bone marrow into man with HIV/AIDS
6. Guy with HIV/AIDS now has T cells that are immune to HIV infection.
7. Guys immune system then naturally fights off HIV infection.
8. Cured!

The drawback? Bone marrow transplants are fatal about 30%-50% of the time. Only about 1% of people have this mutation and most are caucasian. In order for this treatment to work one must not only find a person with this mutation but then have a tissue match with them in order to be able to receive the treatment. Then you must survive the bone marrow transplant...
Edited by Epitope - 6/6/11 at 12:13pm
    
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post #3 of 25
Quote:
Originally Posted by epitope View Post
this story has been reposted several times and is rather old news. I gave a presentation on this 3 years ago in my phd level immunology class.

In a nutshell the cure works like this:
1. Hiv infects t cells
2. T cell precursor cells are created in your bone marrow
3. Hiv requires certain receptor proteins to be on the t cells in order to infect them.
4. Doctors find suitable bone marrow donors that are mutant for those receptors.
5. Doctors transplant mutant bone marrow into man with hiv/aids
6. Guy with hiv/aids now has t cells that are immune to hiv infection.
7. Guys immune system then naturally fights off hiv infection.
8. Cured!
lmftfy..

8. Profit!!!!
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post #4 of 25
Well it is better then nothing. Hopefully 10 years down the line we will have perfected it more.
    
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post #5 of 25
wont we be able to replicate this gene? since we know what causes it.
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post #6 of 25
Quote:
UCSF’s Dr. Paul Volberding, another pioneering AIDS expert who has studied the disease for all of its 30 years cautioned that while “the Berlin Patient is a fascinating story, it’s not one that can be generalized.”
Meaning it's not a full blown cure...

It's a possible cure...

Which is still good news, but not the news others with AIDS victims hoped to hear..
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post #7 of 25
The cure for AIDS is cash.
post #8 of 25
Quote:
Originally Posted by coltsrock View Post
wont we be able to replicate this gene? since we know what causes it.
We know the exact mutation that causes the cure. Conducting gene therapy in order to give people that gene is still beyond our abilities. Gene therapy research is a very controversial topic. There were a few sloppy experiments done that resulted in a young man getting killed in gene therapy research a few years ago and it was almost banned.

Gene therapy essentially involves modifying a virus to infect a persons body but instead of inserting its own viral genome into the host it inserts the desired modified DNA.

Quote:
Originally Posted by 8-Ball View Post
The cure for AIDS is cash.
Not really... Treatments are much more profitable than cures. Thats why most drug companies research treatments. With a treatment you keep taking (and purchasing) a medicine day after day after day. With a cure you do it and you are done... Where is the money in that?
Edited by Epitope - 6/6/11 at 12:49pm
    
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post #9 of 25
Quote:
Originally Posted by Epitope View Post
This story has been reposted several times and is rather old news. I gave a presentation on this 3 years ago in my PhD level Immunology class.

In a nutshell the cure works like this:
1. HIV infects T cells
2. T cell precursor cells are created in your bone marrow
3. HIV requires certain receptor proteins to be on the T cells in order to infect them.
4. Doctors find suitable bone marrow donors that are mutant for those receptors.
5. Doctors transplant mutant bone marrow into man with HIV/AIDS
6. Guy with HIV/AIDS now has T cells that are immune to HIV infection.
7. Guys immune system then naturally fights off HIV infection.
8. Cured!

The drawback? Bone marrow transplants are fatal about 30%-50% of the time. Only about 1% of people have this mutation and most are caucasian. In order for this treatment to work one must not only find a person with this mutation but then have a tissue match with them in order to be able to receive the treatment. Then you must survive the bone marrow transplant...

Are bone marrow transplants really that fatal? The hospital I work for does them all the time, but I work in IT for said hospital. I know three people that have had them for cancer treatment reasons. I didn't think it was anymore risky then say a kidney transplant. Ouch...a minimum of 3 in 10 die from it though?
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post #10 of 25
Quote:
Originally Posted by Epitope View Post


Not really... Treatments are much more profitable than cures. Thats why most drug companies research treatments. With a treatment you keep taking (and purchasing) a medicine day after day after day. With a cure you do it and you are done... Where is the money in that?
No it's totally cash.
http://www.southparkstudios.com/clip...-cure-for-aids
    
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