Maybe, how do they get in the way though when they're right at the edge of the keyboard? Do you just mean you might press one by accident?
In both cases the X4 and Alienware Tactx keyboard which I have used I was pressing the M buttons instead of the escape button a couple of times for the first few hours of use.
But you soon get used to it, it might be slightly harder with the G110 keyboard because it has two rows of G keys.
Usually the keys affected by this are esc, ctrl, left shift, caps lock and tab.