Overclock.net › Forums › Industry News › Technology and Science News › [ctv]Canadian-made HIV vaccine approved for human testing
New Posts  All Forums:Forum Nav:

[ctv]Canadian-made HIV vaccine approved for human testing

post #1 of 94
Thread Starter 
Source
Quote:
Many have tried and failed to create a vaccine that could prevent infection with HIV. Now, Canadian researchers say they're working on one that takes a different approach.

Researchers from the University of Western Ontario in London, Ont. say they have developed an HIV vaccine that uses the whole HIV virus, unlike other attempts that have used just certain genes or proteins from the virus.

The virus has been genetically engineered to be "non-pathogenic," meaning it can't actually cause HIV in recipients. The idea is the vaccine would prime the body's T-cells to destroy any cells that might become infected with HIV.

So far, the vaccine has been shown to stimulate a strong immune response in preliminary toxicology tests in lab animals, the university reports. But it will be several years before researchers know whether it's effective in humans.

...

The World Health Organization estimates that 34 million people are living with HIV around the world, and that 2.7 million people are newly infected every year.


My System
(14 items)
 
  
CPUMotherboardGraphicsRAM
Intel Core i7 2700k Asus p8z68v-lx Intel HD graphics 3000 G.Skill 2x4GB DDR 3 1600 
Hard DriveHard DriveOptical DriveOS
320 GB WD Blue  1TB WD Black Samsung SH232 Win 7 Ultimate x64 
MonitorPowerCase
Samsung P2770 1920x1080 Thermal Take 600 Watt Antec 900 
  hide details  
Reply
My System
(14 items)
 
  
CPUMotherboardGraphicsRAM
Intel Core i7 2700k Asus p8z68v-lx Intel HD graphics 3000 G.Skill 2x4GB DDR 3 1600 
Hard DriveHard DriveOptical DriveOS
320 GB WD Blue  1TB WD Black Samsung SH232 Win 7 Ultimate x64 
MonitorPowerCase
Samsung P2770 1920x1080 Thermal Take 600 Watt Antec 900 
  hide details  
Reply
post #2 of 94
2.7 million a year. Damn people...
New rig
(9 items)
  
Reply
New rig
(9 items)
  
Reply
post #3 of 94
The ethical issues behind testing HIV vaccinations are fascinating. "Here, have an HIV vaccine that we're testing, we don't know if it's 100% effective, but you should have unprotected sex and make as many blood brothers/sisters as possible to see if our vaccine works! Bleed on people! Let them bleed on you! It worked for the guinea pigs, now you get to be the guinea pigs! Science!" I'm glad they have developed a vaccine, but the public backlash against this will be tremendous.
Quote:
Phase II would measure immune responses to the vaccine in people who are HIV negative. Phase III would test the effectiveness of the vaccine in a larger group of about 6,000 volunteers who are at risk of becoming infected. Half would be given the vaccine and half given a placebo. Participants would then be tracked for three years to see how many in each group become infected.

The harshest thing you've ever read.
It's A Computer!
(13 items)
 
Also a Computer!
(15 items)
 
 
CPUMotherboardGraphicsRAM
i5 2500K Gigabyte Z68X-UD4 Asus HD 5850 G. Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Crucial M4 WD Caviar Black Samsund SH-S223A Antec Kuhler 920  
OSMonitorPowerCase
Windows 7 Home Samsung 2443BW HAS Silverstone Strider Plus 750W NZXT Source 210 Black 
Mouse
Logitech G500 
CPUMotherboardGraphicsRAM
AMD PII X4 965BE MSI 790FX-GD70 ASUS HD 4850  G.Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Intel X25-V WD Caviar Blue Samsung S222A Thermalright Venomous-X 
OSMonitorPowerCase
Windows 7 64 Home Samsung S23A Corsair TX750W NZXT Source 210 Black 
Mouse
MX 518 
CPUMotherboardGraphicsRAM
Lapped e2180@3.0GHz Gigabyte GA-G41M-ES2L 9500GT Patriot DDR2@800MHz 
Hard DriveOSMonitorPower
Hitachi 500gb Windows 7 Viewsonic 19" Cooler Master 500W 
  hide details  
Reply
It's A Computer!
(13 items)
 
Also a Computer!
(15 items)
 
 
CPUMotherboardGraphicsRAM
i5 2500K Gigabyte Z68X-UD4 Asus HD 5850 G. Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Crucial M4 WD Caviar Black Samsund SH-S223A Antec Kuhler 920  
OSMonitorPowerCase
Windows 7 Home Samsung 2443BW HAS Silverstone Strider Plus 750W NZXT Source 210 Black 
Mouse
Logitech G500 
CPUMotherboardGraphicsRAM
AMD PII X4 965BE MSI 790FX-GD70 ASUS HD 4850  G.Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Intel X25-V WD Caviar Blue Samsung S222A Thermalright Venomous-X 
OSMonitorPowerCase
Windows 7 64 Home Samsung S23A Corsair TX750W NZXT Source 210 Black 
Mouse
MX 518 
CPUMotherboardGraphicsRAM
Lapped e2180@3.0GHz Gigabyte GA-G41M-ES2L 9500GT Patriot DDR2@800MHz 
Hard DriveOSMonitorPower
Hitachi 500gb Windows 7 Viewsonic 19" Cooler Master 500W 
  hide details  
Reply
post #4 of 94
Quote:
Originally Posted by KittensMewMew View Post

The ethical issues behind testing HIV vaccinations are fascinating. "Here, have an HIV vaccine that we're testing, we don't know if it's 100% effective, but you should have unprotected sex and make as many blood brothers/sisters as possible to see if our vaccine works! Bleed on people! Let them bleed on you! It worked for the guinea pigs, now you get to be the guinea pigs! Science!" I'm glad they have developed a vaccine, but the public backlash against this will be tremendous.
The harshest thing you've ever read.

Because they are forcing the volunteers to volunteer right? rolleyes.gif
Lawlputer
(18 items)
 
  
CPUMotherboardGraphicsRAM
AMD Phenom X3 720 BE 3.5Ghz Asus Crosshair IV Formula VisionTek 6950 2GB G.SKILL 2x4GB Ripjaws X DDR3 2133 
Hard DriveHard DriveHard DriveHard Drive
OCZ Vertex WD Caviar Green WD Caviar Green WD Caviar Green 
Hard DriveOptical DriveOptical DriveOS
WD Caviar Black Pioneer DVD Burner LiteOn DVD Burner Windows 7 Ultimate 64-Bit 
MonitorKeyboardPowerCase
Asus VW266H 25.5" Microsoft Reclusa Gaming Keyboard Antec Truepower Quattro 850W CoolerMaster HAF 932 Limited AMD Edition 
Mouse
Logitech MX518 
  hide details  
Reply
Lawlputer
(18 items)
 
  
CPUMotherboardGraphicsRAM
AMD Phenom X3 720 BE 3.5Ghz Asus Crosshair IV Formula VisionTek 6950 2GB G.SKILL 2x4GB Ripjaws X DDR3 2133 
Hard DriveHard DriveHard DriveHard Drive
OCZ Vertex WD Caviar Green WD Caviar Green WD Caviar Green 
Hard DriveOptical DriveOptical DriveOS
WD Caviar Black Pioneer DVD Burner LiteOn DVD Burner Windows 7 Ultimate 64-Bit 
MonitorKeyboardPowerCase
Asus VW266H 25.5" Microsoft Reclusa Gaming Keyboard Antec Truepower Quattro 850W CoolerMaster HAF 932 Limited AMD Edition 
Mouse
Logitech MX518 
  hide details  
Reply
post #5 of 94
Canada <3
Yeyo
(16 items)
 
Scarface PC pics
(47 photos)
 
CPUMotherboardGraphicsRAM
i7 3770k ASRock Extreme 4 Gen 3 EVGA 670FTW Gskill Sniper Low Voltage Series 1.25v 16GB 
Hard DriveOptical DriveCoolingOS
Intel 80GB G2- OCZ 60GB- 1TB Asus BD combo Megashadow Deluxe Edition  Win7 
MonitorPowerCaseAudio
40" Insignia  Seasonic X750w Sleeved red Corsair 500r White Asus Xonar DGX 
  hide details  
Reply
Yeyo
(16 items)
 
Scarface PC pics
(47 photos)
 
CPUMotherboardGraphicsRAM
i7 3770k ASRock Extreme 4 Gen 3 EVGA 670FTW Gskill Sniper Low Voltage Series 1.25v 16GB 
Hard DriveOptical DriveCoolingOS
Intel 80GB G2- OCZ 60GB- 1TB Asus BD combo Megashadow Deluxe Edition  Win7 
MonitorPowerCaseAudio
40" Insignia  Seasonic X750w Sleeved red Corsair 500r White Asus Xonar DGX 
  hide details  
Reply
post #6 of 94
First thing that came to my mind..... "I am Legend" frown.gif
post #7 of 94
Quote:
Originally Posted by Squirrel View Post

Quote:
Originally Posted by KittensMewMew View Post

The ethical issues behind testing HIV vaccinations are fascinating. "Here, have an HIV vaccine that we're testing, we don't know if it's 100% effective, but you should have unprotected sex and make as many blood brothers/sisters as possible to see if our vaccine works! Bleed on people! Let them bleed on you! It worked for the guinea pigs, now you get to be the guinea pigs! Science!" I'm glad they have developed a vaccine, but the public backlash against this will be tremendous.
The harshest thing you've ever read.

Because they are forcing the volunteers to volunteer right? rolleyes.gif

Actually, it's the "placebo" part that is highly disturbing. If everyone got the same vaccine, it would be okay, since that's what they signed up for in the first place. Now - not so much.
     
CPUMotherboardGraphicsRAM
QX6850 E0 3.60GHz @1.45v Asus P5Q Pro Turbo Gigabyte R6870 OC 2x2GB G.Skill DDR2-1066, 5-5-5-15 
Hard DriveHard DriveOptical DriveCooling
Samsung 840 EVO 120GB Samsung Spinpoint F3 1TB Lite-On iHAS122 CoolerMaster Hyper 212+ 
OSMonitorKeyboardPower
Windows 7 Ultimate SP1 64-Bit Acer X243H 24" Microsoft SideWinder x4 Chieftec BPS-650C 
CaseMouseMouse PadAudio
Aerocool X-Warrior Black Edition Steelseries Kana Skyrim-pad Asus Xonar DG 
AudioOther
Creative Inspire T3100 PS3 controller 
CPUMotherboardGraphicsRAM
Pentium 4 HT Northwood 3.4 @ 3.5GHz ASRock P4i48 Club3D Radeon HD4670 AGP 1GB 2x1GB PQI DDR400 
Hard DriveOptical DriveCoolingOS
SAMSUNG HD320LJ 320GB SATA Lite-On iHAS122 Scythe Katana 3 Windows 7 Ultimate SP1 32Bit 
MonitorKeyboardPowerCase
Samsung SyncMaster 795mb 17" Microsoft Internet Keyboard Gigabyte GE-R460-V1 460W Caseless 
MouseMouse PadAudioAudio
Logitech RX1000 Generic black mouse pad Onboard Creative Inspire T3100 
  hide details  
Reply
     
CPUMotherboardGraphicsRAM
QX6850 E0 3.60GHz @1.45v Asus P5Q Pro Turbo Gigabyte R6870 OC 2x2GB G.Skill DDR2-1066, 5-5-5-15 
Hard DriveHard DriveOptical DriveCooling
Samsung 840 EVO 120GB Samsung Spinpoint F3 1TB Lite-On iHAS122 CoolerMaster Hyper 212+ 
OSMonitorKeyboardPower
Windows 7 Ultimate SP1 64-Bit Acer X243H 24" Microsoft SideWinder x4 Chieftec BPS-650C 
CaseMouseMouse PadAudio
Aerocool X-Warrior Black Edition Steelseries Kana Skyrim-pad Asus Xonar DG 
AudioOther
Creative Inspire T3100 PS3 controller 
CPUMotherboardGraphicsRAM
Pentium 4 HT Northwood 3.4 @ 3.5GHz ASRock P4i48 Club3D Radeon HD4670 AGP 1GB 2x1GB PQI DDR400 
Hard DriveOptical DriveCoolingOS
SAMSUNG HD320LJ 320GB SATA Lite-On iHAS122 Scythe Katana 3 Windows 7 Ultimate SP1 32Bit 
MonitorKeyboardPowerCase
Samsung SyncMaster 795mb 17" Microsoft Internet Keyboard Gigabyte GE-R460-V1 460W Caseless 
MouseMouse PadAudioAudio
Logitech RX1000 Generic black mouse pad Onboard Creative Inspire T3100 
  hide details  
Reply
post #8 of 94
Quote:
Originally Posted by bgtrance View Post

First thing that came to my mind..... "I am Legend" frown.gif

The krippen virus!

I think that was the name.
Yeyo
(16 items)
 
Scarface PC pics
(47 photos)
 
CPUMotherboardGraphicsRAM
i7 3770k ASRock Extreme 4 Gen 3 EVGA 670FTW Gskill Sniper Low Voltage Series 1.25v 16GB 
Hard DriveOptical DriveCoolingOS
Intel 80GB G2- OCZ 60GB- 1TB Asus BD combo Megashadow Deluxe Edition  Win7 
MonitorPowerCaseAudio
40" Insignia  Seasonic X750w Sleeved red Corsair 500r White Asus Xonar DGX 
  hide details  
Reply
Yeyo
(16 items)
 
Scarface PC pics
(47 photos)
 
CPUMotherboardGraphicsRAM
i7 3770k ASRock Extreme 4 Gen 3 EVGA 670FTW Gskill Sniper Low Voltage Series 1.25v 16GB 
Hard DriveOptical DriveCoolingOS
Intel 80GB G2- OCZ 60GB- 1TB Asus BD combo Megashadow Deluxe Edition  Win7 
MonitorPowerCaseAudio
40" Insignia  Seasonic X750w Sleeved red Corsair 500r White Asus Xonar DGX 
  hide details  
Reply
post #9 of 94
You don't understand. They need people who are "at risk". When participating in a drug trial, you either get the drugs for free because they ease symptoms and the pharmaceutical company wants to see the other systemic effects to fine tune dosing as compared to a placebo group, or in this case, you are protected from HIV. Hopefully. Because no amount of placebo effect will stop you from getting HIV.

"At risk" means intravenous drug users, heavy partiers and other young adults and medical workers. How is it fair to any of them to get the placebo. The only reason for the placebo is to see the efficacy of the vaccine- assuming 20% of trial patients come into contact with HIV (that's a reasonable number I think) in a case where they would be infected if they didn't have the vaccine, how is it fair that half of them have no chance of protection? Usually vaccine studies are no placebo. Give them all the vaccine, if 90% of the 20% who come in contact with the vaccine are HIV free, then it's a great vaccine to start using. Don't leave it to a dice roll to decide people's fate.
Quote:
Phase II would measure immune responses to the vaccine in people who are HIV negative. Phase III would test the effectiveness of the vaccine in a larger group of about 6,000 volunteers who are at risk of becoming infected. Half would be given the vaccine and half given a placebo. Participants would then be tracked for three years to see how many in each group become infected.

Have fun placebos. I really hope the author of the article was just generalizing to most drug trials rather than this specific case.
Edited by KittensMewMew - 2/5/12 at 11:52pm
It's A Computer!
(13 items)
 
Also a Computer!
(15 items)
 
 
CPUMotherboardGraphicsRAM
i5 2500K Gigabyte Z68X-UD4 Asus HD 5850 G. Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Crucial M4 WD Caviar Black Samsund SH-S223A Antec Kuhler 920  
OSMonitorPowerCase
Windows 7 Home Samsung 2443BW HAS Silverstone Strider Plus 750W NZXT Source 210 Black 
Mouse
Logitech G500 
CPUMotherboardGraphicsRAM
AMD PII X4 965BE MSI 790FX-GD70 ASUS HD 4850  G.Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Intel X25-V WD Caviar Blue Samsung S222A Thermalright Venomous-X 
OSMonitorPowerCase
Windows 7 64 Home Samsung S23A Corsair TX750W NZXT Source 210 Black 
Mouse
MX 518 
CPUMotherboardGraphicsRAM
Lapped e2180@3.0GHz Gigabyte GA-G41M-ES2L 9500GT Patriot DDR2@800MHz 
Hard DriveOSMonitorPower
Hitachi 500gb Windows 7 Viewsonic 19" Cooler Master 500W 
  hide details  
Reply
It's A Computer!
(13 items)
 
Also a Computer!
(15 items)
 
 
CPUMotherboardGraphicsRAM
i5 2500K Gigabyte Z68X-UD4 Asus HD 5850 G. Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Crucial M4 WD Caviar Black Samsund SH-S223A Antec Kuhler 920  
OSMonitorPowerCase
Windows 7 Home Samsung 2443BW HAS Silverstone Strider Plus 750W NZXT Source 210 Black 
Mouse
Logitech G500 
CPUMotherboardGraphicsRAM
AMD PII X4 965BE MSI 790FX-GD70 ASUS HD 4850  G.Skill Ripjaws 
Hard DriveHard DriveOptical DriveCooling
Intel X25-V WD Caviar Blue Samsung S222A Thermalright Venomous-X 
OSMonitorPowerCase
Windows 7 64 Home Samsung S23A Corsair TX750W NZXT Source 210 Black 
Mouse
MX 518 
CPUMotherboardGraphicsRAM
Lapped e2180@3.0GHz Gigabyte GA-G41M-ES2L 9500GT Patriot DDR2@800MHz 
Hard DriveOSMonitorPower
Hitachi 500gb Windows 7 Viewsonic 19" Cooler Master 500W 
  hide details  
Reply
post #10 of 94
Thread Starter 
Quote:
Originally Posted by KittensMewMew View Post

You don't understand. They need people who are "at risk". When participating in a drug trial, you either get the drugs for free because they ease symptoms and the pharmaceutical company wants to see the other systemic effects to fine tune dosing, or in this case, you are protected from HIV. Hopefully.
"At risk" means intravenous drug users, heavy partiers and other young adults and medical workers. How is it fair to any of them to get the placebo. The only reason for the placebo is to see the efficacy of the vaccine- assuming 20% of trial patients come into contact with HIV (that's a reasonable number I think) in a case where they would be infected if they didn't have the vaccine, how is it fair that half of them have no chance of protection? Usually vaccine studies are no placebo. Give them all the vaccine, if 90% of the 20% who come in contact with the vaccine are HIV free, then it's a great vaccine to start using. Don't leave it to a dice roll to decide people's fate.
Have fun placebos. I really hope the author of the article was just generalizing to most drug trials rather than this specific case.

Yep that's the problem within those 3 years, those people could die. I would think they would be told to discontinue any current HIV medication so they would be 100% its the vaccine working and not the medicine interfering. Of course they never tell those who are taking the placebo that they are and that they must follow everything the real vaccine takers are doing. Including but not limited discontinuing the meds the are helping them currently.
My System
(14 items)
 
  
CPUMotherboardGraphicsRAM
Intel Core i7 2700k Asus p8z68v-lx Intel HD graphics 3000 G.Skill 2x4GB DDR 3 1600 
Hard DriveHard DriveOptical DriveOS
320 GB WD Blue  1TB WD Black Samsung SH232 Win 7 Ultimate x64 
MonitorPowerCase
Samsung P2770 1920x1080 Thermal Take 600 Watt Antec 900 
  hide details  
Reply
My System
(14 items)
 
  
CPUMotherboardGraphicsRAM
Intel Core i7 2700k Asus p8z68v-lx Intel HD graphics 3000 G.Skill 2x4GB DDR 3 1600 
Hard DriveHard DriveOptical DriveOS
320 GB WD Blue  1TB WD Black Samsung SH232 Win 7 Ultimate x64 
MonitorPowerCase
Samsung P2770 1920x1080 Thermal Take 600 Watt Antec 900 
  hide details  
Reply
New Posts  All Forums:Forum Nav:
  Return Home
  Back to Forum: Technology and Science News
Overclock.net › Forums › Industry News › Technology and Science News › [ctv]Canadian-made HIV vaccine approved for human testing