if you have the room on your desk
book shelf speakers will pound on pretty much all computer speaker options
I have polk bookshelf speakers and a T-amp... which I love (specifically T15 bookshelf speakers I got for $49 (pair) on sale and a SMSL SA-S3 t-amp
i still need to get a sub however.. just haven't got around to it.
a popular option (cause they are frequently on sale for $80-90~) on newegg are the polk M30 bookshelf speakers and T-Amp (with DTA-100a t-amp) and a powered sub
newegg has these on sale for $69 pair now... I have heard good things about these Pioneer speakers
these speakers are another popular choice (cause they sound nice and are hella cheap)
many people also have Swan powered speakers for their computers
this set is kinda awesome and wouldn't take as much desk space as bookshelf speakers I suppose.
and of course the M200MKII