Wall of text incoming!
I've been having a strange issue with my X79 Extreme4 board since I bought it in mid-August. The only way I can describe it is that it likes to randomly lock up when playing audio. When it happens, any video currently playing stops and my input devices stop responding. The only way to fix it is to hard-reboot. I've updated the BIOS, set the BIOS settings back to defaults, ran memtest for 3 hours with no issues, ran Furmark fullscreen with CF enabled for roughly an hour with no issues, switched the BIOS switch on my 6950s back to stock, and uninstalled all the junk software that was on the driver disk.
After I did all this, the problem seemed to go away for a few weeks, but started happening again this past weekend while playing Skyrim. I've noticed that it likes to happen when a sound effect is supposed to play because it did it when I pushed R to put an item into a chest, and then it did it again later when an arrow I fired hit an enemy. It also did it once when I clicked M1 to fire a gun in Max Payne 3. On the flip side, it has also done it when either watching a video or listening to music.
I'm using a G35 plugged into one of the USB 2.0 ports on the front of my case. I've been doing some research and found that the Z77 and X79 boards have been having issues with the 3.0 headers recently. Could this have something to do with it? I think the two USB 2.0 ports are going through a USB 3.0 header since there is one 3.0 port on the front and the only USB connector coming from the front of the case into the chassis is a big 3.0 plug.
Here's another weird part: I was running GPU-Z on one of my other monitors to see if maybe my graphics cards were overheating, and when Skyrim eventually locked up, GPU-Z was still monitoring in real-time. This means the system isn't completely locking up, but seems just lock up all my USB peripherals.
TL;DR: Playing sound sometimes results in video locking up and all my USB devices stop responding. No OCs on anything, default BIOS settings, no BIOS mods on the 6950s.
It's killing my will to play anything because I don't know if/when it's going to lock up. Any ideas?
EDIT: Looks like ASRock put up a beta BIOS on the 15th... I'll give that a shot later this evening, though I kind of doubt it will fix the issue.
Edited by JSkater - 10/22/12 at 6:34pm