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March Foldathon (19th-21st) - Raising Awareness for Osteogenesis Imperfecta & Ehler-Danlos Syndrome [Stats/Prizes Posted]

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Thread Starter 

3) March.png

-credit to Lutro0 for the logo-


 

Quote:
Originally Posted by zodac View Post

Prizes:

• $25 PayPal - donated by admin - solsamurai

• $25 PayPal - donated by admin - blazed_1

• $25 PayPal - donated by admin - elchucko

 

• Lifetime Overclocked account - donated by admin - k4m1k4z3

• Lifetime Overclocked account - donated by admin - SpYFoXZeRo

 

• $50 PayPal - donated by BWG - thurst0n

• 2x Arkham City (Steam) - donated by PR-Imagery (US only) - SectorNine50 & danielwiley

• Indie Steam game of your choice (up to $40) - donated by axipher - P1LGR1M

• Dirt3 (Steam) - donated by MacG32 - evilghaleon

• 2x 1lb Marshmallow Mint Fudge - donated by Philistine - brownieapple & 1337LutZ

 

Also, Demented has offered the following prizes, for new Foldathon Folders only:

• Asus EN8400GS - khkim

• X-Fi XtremeMusic soundcard (PCI) - krista031

• Hauppauge WinTV-HVR-1800 MCE TV Tuner card - aas88keyz

 

Referral Prize Draw

1st place - OCN Ducky keyboard (switch of their choice) - juano (99,336pts)

2nd place - $50 through PayPal - Alatar (14,812pts)

3rd place - $25 through PayPal - BWG (10,289pts)

Random OCN Ducky keyboard - sweffymo

Remaining Referral Points (Click to show)

4th - Deathclaw (6,707pts)
5th - derickwm - (4,195pts)
6th - sweffymo - (1,588pts)
7th - adcantu - (0pts)
8th - Citra - (0pts)

 

PMs might be out later. It's a lot of effort, and I don't like effort, so I might just not bother.

 



 

Quote:
Originally Posted by zodac View Post

Stats time!

 

Points: 39,241,097 (6,399,060 less than February)

Folders: 427 (51 less than February)

New Active Folders: 41 (22 less than February)


Not as good as last time... but still, just under 20mil PPD, and I don't think there's much shame in that. :D A bit annoyed we lost 50 Folders though. :P

 

We have the referrals as well this month, and I'll post the results of that with the prizes shortly (or you can work it out yourself; it's basic addition).

 

Final stats for this month. :thumb:

 

 

 

 

What is the Foldathon?

The Foldathon is a 2-day period each month where we Fold on any and all clients we can get our hands on. You might not be able to Fold 24/7, but if you're a Folder, there's no excuse not to Fold for these 48 hours.

 

This year, we're using every second Foldathon to highlight some of the lesser known diseases that the Folding@Home Project researches (directly or indirectly). In the spot light this month are two diseases:

Osteogenesis Imperfecta and Ehler-Danlos Syndrome

 

Quote:

Just before I begin, I'd like to point out that OI and EDS are both separate diseases, but the protein at fault is the same in both, so it made sense to group together the commonalities. Plus it was so much easier.

 

The Diseases

OI and EDS are both uncommon/rare genetic diseases which affect bones and joints. OI - also known as "brittle bone disease" - is a bone disorder which results in bones breaking easily, with little or no cause, and taking longer to heal. EDS is a group of disorders with the connective tissue in the body; the tissue that supports the muscles and ligaments. It also has a nasty effect of resulting in fragile and "stretchy" skin. As you might expect, sufferers of either disease are usually in constant pain.

As with most of the diseases being researched by the Folding Project, there are no cures for OI or EDS.

 

The Cause

Both are caused by a faulty gene which leads to lack of - or defective - protein in the body, named "collagen". Genetically, if one parent has the fault gene, the odds are 50:50 that their child will also have the disease. Unlike other diseases like Huntington's (where the gene can remain dormant for years before "striking"), symptoms are always around from the day of birth. In most cases (since the majority are not extreme), many people believe the pains to be due to normal injuries and muscle aches. However, as you grow older, the pain and deformations become more prominent.

 

I've put a little bit more technical info in a spoiler, for those interested in reading into it in a bit more depth:

Detailed OI/EDS info (Click to show)

The fragile skin and extremely loose joints associated with EDS are essentially caused by the abnormal protein, which means that the muscles and joints in the body simply don't have enough collagen to do their job. Shoulders, knees, elbows, fingers; all these joints can become hypermobile with the limbs rolling in and out of their sockets.

One of the other major disorders is hyperextension of the skin. The blood vessels of the skin are also weakened by EDS, meaning sufferers bruise very easily, which makes contact with the skin very painful.

 

In the case of OI, bone brittleness also occurs when "hydrolysis" fails. Hydrolysis in this case refers to the breaking down and absorbing of defective collagen, so new proteins can take their place.

When this fails, the relationship between the collagen fibrilis and hydroxyapatite crystals that form the bone is altered, and the body ends up with brittle bones.

 

 

The Symptoms

Osteogenesis Imperfecta (Click to show)

 

Common (Type I, III, IV)
• Loose joints

• Weak muscles

• Tinted sclera (blue/purple eyes usually)

• Curved spine

• Hearing loss

 

While this form of OI is very difficult to live with (dislocations and fractures are very common), it is not fatal.

 

Severe (Type II)

• Can be lethal at birth (due to respiratory issues)

• Small stature

• Underdeveloped lungs

• Numerous bone fractures and severe bone deformity

 

Type II OI, when present at birth, usually results in the child not surviving beyond a few weeks, due to the poorly-formed lungs, as well as the possibility of cardiac complications.

 

 

Ehler-Danlos Syndrome (Click to show)

 

Classical (Type I and II)

• Skin hyper-extensibility, with atrophic scarring (Google it; images explain it better).

• Hematomas are commonly found on scarred areas on pressure points (elbows, knees, forehead, etc).

• Leads to sprains, dislocations and an easily bruised body.

 

It is among the more visible forms of the disease, due to the extensive scarring among older sufferers.

 

Hypermobility (Type III)

• Extreme looseness of the joints.

• The shoulders, knees and jaw often dislocate.

• Chronic joint and limb pain.

 

One of the less well-known, but certainly one of the most painful manifestations of EDS.

 

Vascular (Type IV)

• Skins is very thin, and almost translucent; veins can often been seen through the skin on the chest/torso.

• Certain facial characteristics; large eyes, thin nose, lobe-less ears.

• Minor trauma often leads to extensive bruising, due to a decrease in subcutaneous tissue.

• Pregnancies for women with Type IV EDS are complicated by the increased likelihood of ruptures in the uterus and arteries.

 

The most serious form of EDS, is there is a risk of organs or arteries rupturing. The life expectancy of people with this form is in the region of 30-40 years.

 

 

The Medication

Treatment is difficult to find, since the conditions are quite uncommon. Most of it is preventative care:

• Wearing braces to prevent dislocations.

• Physical therapy to strengthen muscles to keep joints in place.

• Pain management (including steroid injections, acupuncture, etc).

 

However, as the diseases progress, narcotics become necessary, eventually leading to replacing joints or even fusing joints together (as a last resort for elderly sufferers), due to the extensive damage.

 

Other Information

Personally, I'd never heard of these diseases (and considering "brittle bones" to be a minor thing in most cases). And one of the bigger issues is the mental pressures it puts on the patients. Since it isn't well known (and information isn't available in massive quantities), it's hard to find friends - and even doctors in some cases - who understand why they're actually in such pain, and seem to be depressed so often. As a result, it's difficult finding someone who can deal with the inevitable bad days, when even getting out of bed can be excruciating, and most sufferers of OI/EDS remain alone for their lives and need to cope with things themselves.

 

Links and videos

Links and videos for OI and EDS (Click to show)

 

 

How it works:
Run Folding@home for Overclock.net (team number: 37726) during the specified times. Those who Fold will be entered into a drawing to win the prizes listed below. If you don't know what Folding@home is, feel free to make a thread in the forum or check these guides:

CPU and/or GPU Folding
Client for AMD GPUs only

 

When:
Monday March 19th Noon EDT (GMT: 4pm) until March 21st Noon EDT.
Countdown

 

 

Prizes:

• $25 PayPal - donated by admin

• $25 PayPal - donated by admin

• $25 PayPal - donated by admin

 

• Lifetime Overclocked account - donated by admin

• Lifetime Overclocked account - donated by admin

 

• $50 PayPal - donated by BWG

• 2x Arkham City (Steam) - donated by PR-Imagery (US only)

• Indie Steam game of your choice (up to $40) - donated by axipher

• Dirt3 (Steam) - donated by MacG32

• 2x 1lb Marshmallow Mint or Butterfinger Fudge - donated by Philistine

 

Also, Demented has offered the following prizes, for new Foldathon Folders only:

• Asus EN8400GS

• X-Fi XtremeMusic soundcard (PCI)

• Hauppauge WinTV-HVR-1800 MCE TV Tuner card.
 

Extra prizes this month:

 

Quote:

As he did in January, admin has a few extra prizes for this Foldathon, using the same referral system, outlined below.

 

1) You refer someone to the Foldathon, and they name you as the referrer.

2) Any points they make for the Foldathon will then be the referrer's "Referred Points".

3) The three members with the most RPs will then win the following prizes:

 

1st place - OCN Ducky keyboard (switch of their choice)

2nd place - $50 through PayPal

3rd place - $25 through PayPal

 

In addition, anyone who refers someone to the Foldathon (and they participate :P) will then also be entered into a random draw for another OCN Ducky keyboard. :D The new users that were referred to the Foldathon will of course be entered into the main prize draw above. :)

 

 

So plenty of reason to get new people signed up this month; extra prize draw for you, and for them. :D

 

SignUp:
You only need to sign up once.

PM me if you'd like to be put on a PM reminder list for all future Foldathons.


----> SIGN UP HERE <----

 

 

Stats:
Courtesy of sks72, enter your name (during the Foldathon) into the following link to see your points total for the Foldathon so far:
Super duper script


 

Sig Link:

[CENTER][B]:cheers: [URL=http://www.overclock.net/t/1227683/march-foldathon-19th-21st-raising-awareness-for-osteogenesis-imperfecta-ehler-danlos-syndrome]March Foldathon (19th-21st) - Raising Awareness for Osteogenesis Imperfecta and Ehler-Danlos Syndrome[/URL] :cheers:[/B][/CENTER]


Edited by zodac - 3/21/12 at 11:35am
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post #2 of 851
First.
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post #3 of 851
One more!
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post #5 of 851
In on this one too!!
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post #6 of 851
no fudge sad-smiley-002.gif
post #7 of 851
Thread Starter 

There's fudge. Why can't people read?

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post #8 of 851
Fudge is in OP now.
Z needs 3 edits to get the OP done right.
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post #9 of 851
Because Z this is the Internet. teaching.gif
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post #10 of 851
Thread Starter 
Quote:
Originally Posted by csm725 View Post

Fudge is in OP now.
Z needs 3 edits to get the OP done right.


Yup:

 

1) To add the thread link into the OP.

2) Fix some of the extra spaces the RTE causes.

3) People wanted fudge.
 

 

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Megadoomer
(14 items)
 
Family Computer
(13 items)
 
 
CPUMotherboardGraphicsRAM
Phenom II X6 1090T @ 4.0Ghz ASUS M4A89GTD PRO Sparkle GTS 450 2x4GB G-Skill Sniper 
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Samsung F1 1TB CM Hyper 212+ Windows 7 Professional x64 Samsung T220 
KeyboardPowerCaseMouse
Logitech MX3000 Laser CM 1000M HAF 922 Logitech VX Revolution 
CPUMotherboardGraphicsRAM
Q6600 Asus PN5-D 750i Evga GTS 250 2x2GB Crucial Ballistix 
Hard DriveOptical DriveOSMonitor
750GB Hitachi Samsung Super Writemaster Windows 7 Professional x64 19" Dell 
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