It has been suggested that the sudden explosion of what is considered fundamentally human: consciousness, culture, language, and intellect is a consequence of our evolved capacity to imitate (Donald, 1993). That the driving force for this cultural explosion was the generation of a second environ-mental space in which memes drove biological selection as well as genes (Blackmore, 1999). A meme is a replicator, a cultural unit operating under Darwinian evolutionary principles analogous to a gene, but a distinct replicator in its own right (Dawkins, 1976; Goodenough and Dawkins, 1994). A meme in layman terms is a concept or idea, embodied by a word, a phrase, a riff, image, or gesture. A meme “exists” in the world of ideas and replicates by imitation. Memes are fluffy, non-delineated concepts rendering them somewhat untouchable by cognitive neuroscience albeit that they share considerable functional overlap with a seminal discovery in neuroscience. Over a decade ago mirror neurons, encoding the intention of “others,” were discovered (Gallese et al., 1996; Rizzolatti et al., 1996). It was quickly proposed that these neurons, located in regions highly involved in imitation, were the neural substrates upon which language could have evolved (Rizzolatti and Arbib, 1998). The biological observation of neurons facilitating action recognition and replication fully supported a theory of memetics (Blackmore, 2005) and the field of memetics has grown (Heylighen and Chielens, 2008). However cognitive neuroscience has given the idea a fairly wide birth, probably due to the aforementioned non-measurable, indefinable nature of memes. This paper briefly reviews the biologically based work on the evolution of language. The paper concludes cognitive neuroscience can, and should, apply considerable weight to the investigation of memetics. Firstly, the paper suggests that although memes may not be quantifiable, the traces of the neural processes involved in memetic replication and storage within the central nervous system (CNS) are measurable. Producing artificial memes for study is easily achieved and has already been done within experimental protocols in a number of fields (see Do We Measure Memes Already?). Modern neuroimaging techniques enable us to quantify changes in neural-network-functional-connectivity-profiles as we perceive, learn, memorize, imitate, or perhaps more accurately “replicate” memes.