... our long term goals have been to:
1) Develop new methods to tackle the computational challenges of simulating protein folding.
2) Apply these methods to gain new insights into protein folding.
3) Use these methods and new insights to simulate Aß protein misfolding, a key process in the toxicity of Alzheimer's Disease (AD).
4) To use those simulations to develop new small molecule drug candidates for AD.
In the early years of FAH, we concentrated on the first two goals above. In the last 5-7 years, we have worked to accomplish the third goal. I'm now very excited to report our progress on the last goal –– using FAH for the development of new therapeutic strategies for AD.
In a paper just published in the Journal of Medicinal Chemistry, we report on tests of predictions from earlier Folding@home simulations, and how these predictions have led to a new strategy to fight Alzheimer's Disease. While this is not a cure, it is a major step towards our final goal, some light at the end of the tunnel...
Very promising news for AD!
Edited by zodac - 3/23/12 at 4:59am