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Folding@Home simlulations lead to new theraputic strategy for Alzheimer's Disease

post #1 of 22
Thread Starter 

More info available at source

 

Quote:

... our long term goals have been to:

1) Develop new methods to tackle the computational challenges of simulating protein folding.

2) Apply these methods to gain new insights into protein folding.

3) Use these methods and new insights to simulate Aß protein misfolding, a key process in the toxicity of Alzheimer's Disease (AD).

4) To use those simulations to develop new small molecule drug candidates for AD.

 

In the early years of FAH, we concentrated on the first two goals above. In the last 5-7 years, we have worked to accomplish the third goal. I'm now very excited to report our progress on the last goal –– using FAH for the development of new therapeutic strategies for AD.

 

In a paper just published in the Journal of Medicinal Chemistry, we report on tests of predictions from earlier Folding@home simulations, and how these predictions have led to a new strategy to fight Alzheimer's Disease. While this is not a cure, it is a major step towards our final goal, some light at the end of the tunnel...

 

Very promising news for AD! band.gif


Edited by zodac - 3/23/12 at 4:59am
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post #2 of 22
thumb.gif Keep up the awesome work guys
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post #3 of 22
wheee.gif

Awesome news. It's only a step towards developing a new strategy to fight it, nonetheless it's pretty amazing stuff
post #4 of 22
cheers.gif
 
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post #5 of 22
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post #6 of 22
We may enjoy the contest, we may be enthralled by the competition, we may just be insanely obsessed with folding, but this my friends is what it is all about. I've devoted a good portion of my life to F@H, it has become my cause of choice to support in any and every way I can and this is why. Congrats to all of those who helped by contributing your computer's resources and more so to those wonderful scientist who put the research to work. I hope they realize just how much this means to those of us that spend most/all their free time and most of our spare money to help the project (not to mention those affected by these horrible diseases).

This is truly why I fold. Cheers. cheers.gif
Edited by WonderMutt - 3/23/12 at 6:16am
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post #7 of 22
Great news for HD sufferers to. Woop woop thumb.gif
post #8 of 22
Thread Starter 
Quote:
Originally Posted by WonderMutt View Post

We may enjoy the contest, we may be enthralled by the competition, we may just be insanely obsessed with folding, but this my friends is what it is all about. I've devoted a good portion of my life to F@H, it has become my cause of choice to support in any and every way I can and this is why. Congrats to all of those who helped by contributing your computer's resources and more so to those wonderful scientist who put the research to work. I hope they realize just how much this means to those of us that spend most/all their free time and most of our spare money to help the project (not to mention those affected by these horrible diseases).

This is truly why I fold. Cheers. cheers.gif


thumb.gif
 

 

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post #9 of 22
Thread Starter 

Bumping this because it's awesome. :)

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post #10 of 22
Nice bump zodac. Thank you for the links.smile.gif
    
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