The only thing that could permanently damage your RAM (apart from accidents such as power surges or physical mistreatment) is overvolting them too much.
It is false to think that overclocking your memory will provide no gains in every real-world app. Granted, this depends on the intensiveness of the task, the app, etc. Damric's tests showed that there was more FPS benefit to be had by improving the memory bandwidth, than by overclocking two GPUs. Some programs will see a large benefit. Many programs will see little to no benefit; that doesn't mean that the indeed existing benefits of improved system memory bandwidth on today's platforms should be ignored. For example: if you find yourself often compressing/decompressing large files with WinRAR, that is where you will see a great benefit with improved bandwidth.
Do what you can with the time you have.
Edited by xd_1771 - 5/20/12 at 7:15pm