Ok, a few things that need to be addressed (some NEED to be addressed, others are nitpicks):
1. Airflow. Your main components have no flow. I know water cooling is to eliminate the need for case fans overall, but it still needs air flowing over the motherboards sinks. Unless you plan on watercooling EVERYTHING on that motherboard, it will need some sort of cross wind. In intense gaming your South Bridge can clear 60C in a well ventilated case. Let alone one with stagnant air.
2. Hiding some components. In my opinion, power supply, hard drives, optical drives, should be hidden in this sort of scenario. A compartment under the motherboard tray would be fine for this use. The goal is to show off the motherboard/video card/water cooling loop, y'know?
3. Tightening the size of the motherboard area, putting a crossflow radiator on both sides, should allow you good air flow as well as good cooling. I believe XSPC EX line of radiators uses the crossflow barbs now, as well as another brand. This will allow you to have the lines going around the area in a straight sorta way, complimenting the boxy area you're storing components.
So here, rough sketch in MSPaint of what I'm talking about.

For an inline pump solution, I'd recommend a top like this (unless a TRUE in-line can be found):
http://www.frozencpu.com/products/13151/ex-pmp-135/Phobya_Laing_DDC_MCP35x_Series_Pump_Top_-_Silver_Nickel_52099.html?tl=g30c107
That'll allow you to have the water come in on the side, and come out the top with a 90 degree fitting and keep that in line look. This entire setup should require very few angled fittings, reducing cost as well. For a complete straight line loop, you'd be looking at 2 angle fittings for the processor, and 1 per pump. If you get a Frozen-Q res, you can do a helix that'll glow to match your build, and also make it completely in line as well, for a nice clean install.
Hope that helps!
EDIT: You can move the pump/reservoir to the front of the motherboard to push the motherboard to the back of the cage as well. This might allow you an even cleaner install because you can hide the pumps that way and only show the rest in the front of the desk (maybe an acrylic window on the front?) as well as also making all connections to the motherboard at the back of the motherboard tray area.