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Yes. Any RAM that is not exactly the same will put extra load on the memory controller on the CPU. The issue though is how much extra load it will put onto the CPU. If the RAM is extremely close together in terms of specifications, then the amount of load that is added is reduced, but load is still added.
I have two different ram kits. 1 is a 2000mhz ram kit at 9-9-9-28 1T and the other is the same except the timings are 9-10-9-28 and it is 1.65v VS. 1.6v.
Even though I have them both clocked at 1600mhz at 8-8-8-20-1T at 1.5v I still have to add some extra CPU voltage to get my CPU up to 4.9ghz.






