"C:\Program Files (x86)\Maxis\SimCity 4 Deluxe\Apps\SimCity 4.exe" -CPUCount:1 -eh:off -intro:off -CustomResolution:enabled -r1920x1080x32 -d:hardware
That is the target I use for SimCity 4. SimCity 4 has a problem with multi-core PCs. And of course, its interesting to note that it supports any resolution, but it only lists 3 in the game options.
Replace C:\Program Files (x86)\Maxis\SimCity 4 Deluxe\Apps\SimCity 4.exe with your own location, and it should work great. Oh, and you can change the resolution to match your own monitor.
Regardless, always remember: Save often. Ctrl+S to quickly save.
Edit: I have yet to have any crashes using this target, but I still save often just in case.
Edited by Neighborbob - 10/18/12 at 12:36pm