JRiver Media Center was designed from the ground up for audiophiles. it has a great layout with organizing, really powerful ripping tool with multi-drive support as mentioned, 64-bit engine, parametric equalizer, convolution engine, memory playback, really advanced upsampling, HDTracks integration, great SACD support, AIFF and ALAC encoding, headphone DSP, etc.
download the trial. if you don't like it, don't buy it
+3 to that. Been using JRiver MC on 4 systems (1 license gives you this).
Not to mention a great Theater View for easily scrolling through giant libraries, and many, many other great things - Video being another...