Originally Posted by zinfinion
You can actually claim multiple city plots this time around.
Indeed. Playing it in person I think they intend for what the game labels a region to function as what a large city did in other games. Especially with the "great work" or whatever it is called with an international airport/nasa/business/ect wonder shared through the region. The ease of moving resources between the cities also enforces this idea.
At launch I'm going to claim 3 cities, two of them I'll only put a little suburban/commercial area, and build up the third with a giant windfarm, massive industrial section, waste management and fill the rest with enough residential commercial to keep the city functioning. Then I'll build the next one up as a "college town" to supply educated sims and enough commuter housing, and use the third city entirely as high-density commercial/residential "downtown". If I'm seeing the systems correctly, it should work using the first city to fund the other two until it reverses.