-Why do you Boinc?
I have the hardware and I no longer utilize it for gaming to any real extent. It is nice to apply my hardware to a good cause. My first BGB got me addicted to BOINC-Have you ever Folded?
Not for F@H, I almost set it up once but did not. I don't remember why.-Do you think Boinc is better than Folding and why?
Yes, simply due to its variety. You can work on biologically relevant projects or CSE or mathematics etc. You can tailor your BOINC project profile to be what you want.-Which is program/app (Boinc/F@H) is easier to use and why?
I cannot honestly say if F@H is easier or not. By all accounts F@H is "plug'n play". BOINC is relativley easy to setup initially. It's the fine tunning your settings to optimize ppd for specific prjects that can become more time consuming (not difficult), you just need to play with it. To anyone who optimizes OCd hardware this tinkering would likely be simple. The optimizations are part of what make BOINC fun.-Do you believe that the Projects that BOINC run i.e. "IBM's WCG HCC, Rosetta@Home, Poem@Home" are just as beneficial to finding cures for cancers and diseases and Folding@Home?
Absolutely equivalent if not more helpful, depending on the project. explained below.-Did you know that Folding@Home actually wanted to come to Boinc? F@H on Boinc
at the bottom
No I was not aware.IMO:
BOINC is a better project, that's as a Biochemist who knows much and is heavily invested in proteins. The computational methods used to determine or attempt to determine protein folding are very controversial. There are so many variables, amino acid electronic interaction, van der waals forces, hydrophobicity, secondary structural, sulphur crosslinks, tertiary structure, solvent effects, protein chaperons(super important) etc etc etc, that they cannot include all variables. The calcs are best case guesses with many approximations and a laboratory biochemist will tell you that the computational guys have a loooong way to go before we are even close to accurately simulating such a complex system.
Besides, Proteins folding correctly is only one of many aspects of a protein and it completely ignores many aspects which are imo more important. Catalytic activity, enzymatic mechanisms, protein-protein and protein-receptor interactions are all as important or more important for drug treatment and other types of therapy. To this end there are many projects on BOINC that approach some of these issues.
When we do understand how proteins actually fold, then what? The body still has x disability because enzyme y does not fold correctly. Gene therapy could be used to augment the gene for expression/transcription/translation of this correctly folded protein, but we are not actually augmenting the protein folding. Just implanting the correct gene for a correctly folding protein.
The understanding of protein folding is beneficial in the long term goal of designing our own proteins to fulfill a desired catalytic activity. To this same end understanding the mechanistic characteristics of an enzymatic active site are much more beneficial. You can have a properly folded designer protein all day long, with 000000000 activity/usability if the active site does not have catalytic activity. Knowing how to impart such activity is far more important.
I think many people just fold because it is popular and they want to feel like part of the group. Just my opinion.Edited by Biorganic - 3/11/13 at 10:48am