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Originally Posted by John Timmer 
In recent years, researchers in the messy world of biology have been able to build systems that function like the clean, binary switches on computer chips—and we've covered a number of reports in this area. Unfortunately, most of these share a significant limitation: they rely on proteins from bacteria that act as switches to turn genes on and off under specific conditions. We know about only a limited number of these genetic switches, which may set a severe limit on the number of logical operations we can string together inside a cell.

A paper in this week's PNAS describes a system that may allow us to get around this limitation. The new method takes a protein from a virus that infects bacteria and cuts it in two, making a pair of genes (A and B) that each produce part of the mature protein. The two parts then act as a biological version of an AND logic gate, with output (in the form of protein activity) present only when both A and B interact. When either or both A and B are missing, the output is off.

In biological terms, the inputs usually involve a simple molecule that can be sensed by proteins inside a bacteria. This paper, for example, used two kinds of sugars (arabinose and lactose). When the sugars are present, they attach to proteins inside the cell, activating genes that are controlled by those proteins. To make an AND gate, you need to design a bit of biology that can respond to both of these signals—it should be active only when both a gene regulated by arabinose and a gene regulated by lactose are each active.

This has been done in a variety of ways in the past, but the authors of the new paper (both faculty at Rice University) come up with a clever scheme for doing so. It's clever in part because it's so remarkably simple.

Wetware advances: Biological logic gate built by splitting viral gene


Still wonder if wetware will ever match silicon. Common Mother Brain!
Dynamix
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Dynamix
(15 items)
 
  
CPUMotherboardGraphicsRAM
i7-860 Gigabyte GA-P55A-UD4P Radeon 7970 Corsair Domintor Twins + Other = 16 Gb 
Hard DriveHard DriveOptical DriveCooling
WD Caviar Black, 500gb OCZ Solid 3 Sony Optiarc Corsair H50 
OSMonitorKeyboardPower
Windows 7 Ultimate Samsung P2570HD + Other Logitech G110 Corsair 750W HX 
CaseMouse
Antec p183 Logitech MX Revolution 
  hide details  
Reply