Download a profile, double click it so it copies the file to the correct Windows folder. Once that's done open Control Center ▸ Color Management and then add the profile to the system by clicking the Add button. Click on the Advanced tab and look for Display Calibration. Calibration curve loading is enabled by the Use Windows display calibration checkbox but it is not sensitive. This can be enabled by clicking on Change system defaults and then returning to the Advanced tab and then clicking the checkbox.
Hopefully that helps. You should see a huge difference with a calibrated icc profile.
Not without having a a software doing it. I am using DisplayFusion for multiscreen tools and I love it. It happens ot be on steam sale every now and then and I paid 7 or 8 euros (~$10) for mine. It also has a free version which gives you plenty of good options too and one of them is to have different wallpapers on each monitors. It supports different resolutions and all that so give it a try. I'm sure you'll like it.
Edited by Vesanius - 12/14/13 at 1:08pm