Originally Posted by SSJVegeta
Well, I won't be using Quad SLI, it will be Quadfire consisting of MSI 7950 Twin Frozr III Boost Edition cards. The rig will be used for mining cryptocurrency and occasional gaming.
The motherboard I'm thinking of is the Gigabyte GA-X79-UD3 as the PCI-E slots are not close together.
You really should look into water cooling or at least blower style coolers. The Twin Frozr III blows the air all about inside the case, without removing it. Which means they are great for a one or two card setup, but not ideal for three-way or four-way.
Using four cards with basically no space in between each card (such as what will occur on that motherboard you mentioned) will cause your temperatures inside the case to be terrible. This will effect your graphics cards, as well as the processor, and motherboard temperatures.