Originally Posted by DarkrReign2049
With Virtual box you can have a dedicated mouse and keyboard for a VM. Once you create a VM go into the settings and go the USB section on the left and add a filter. Then choose your mouse or keyboard and it should only work in the VM, make a filter for both separately. I just tested it with a keyboard and it worked. I don't think you will be able to do it with Hyper-V in 2012 though.
The problem with that is that it's incredibly slow. Also how you're going to get the video signal across the house is going to be costly. Either HDMI/DVI over Ethernet adapters or Thinclients. If you use Thinclients you'll need your VMs to run Windows 8 for RemoteFX or use Server 2008's methods for using RemoteFX (which would be expensive to license.)
I don't know what kind of server you have laying around but you're probably better off with everyone bringing their own machine.