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[YT] Cancer cells defeated by HIV - Fire with Fire - Ross Kauffman - GE FOCUS FORWARD

13K views 123 replies 67 participants last post by  un-midas touch 
#1 ·
Had a quick search, couldn't find anything about it on OCN.

Found this while browsing LiveLeak. I know it's not technology news, but it is science! And good science is awesome.
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Quote:
Who would dare to pit one fatal disease against another... inside the body of an six-year-old patient? The results will shatter all expectations.
 
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#3 ·
Awesome science we have here. Glad to see HIV can be repurposed in so many ways, especially against Leukemia.

The trick just lies with the surface markers on both the cancer cells and the matching pairs on the virus.

Glad I'm studying molecular bio for now though the work I do is a bit limited compared to this stuff. Too bad I don't work on cures, just diagnostics.
 
#7 ·
Quote:
Originally Posted by Vlasov_581 View Post

so this is a genetically engineered HIV virus, meaning that it doesn't have the code in its DNA to act like the dangerous and fatal version of it like the one that we face in the world?
Exactly. The general idea seems to have been to "reprogram" the HIV virus to attack cancerous cells, while disabling the part that, you know, destroys the immune system.
 
#8 ·
Quote:
Originally Posted by Alecthar View Post

Exactly. The general idea seems to have been to "reprogram" the HIV virus to attack cancerous cells, while disabling the part that, you know, destroys the immune system.
Thats great even if it harmed the body hiv is the lesser of the 2 evils when it comes to certain cancers that you only have a few years to live if that long and people on the right meds with hiv can live a very long life.
 
#9 ·
Quote:
Originally Posted by Alecthar View Post

Exactly. The general idea seems to have been to "reprogram" the HIV virus to attack cancerous cells, while disabling the part that, you know, destroys the immune system.
That isn't exactly correct. If you watch the video, it's using HIV viruses with modified DNA to "attack" T-cells extracted from the patient and reprogram those T-cells. The T-cells are then introduced back into the patient, where they replicate and then attack the cancer cells.
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Originally Posted by jsc1973 View Post

So we can figure out a way to use HIV to cure leukemia, but we can't figure out a way to cure HIV? Go figure.
Reprogramming (altering DNA sequences) isn't hard, and it's been something we can do for many years now.

Scientists haven't even figured out a way to destroy viruses without harming regular cells. All vaccines do is get the immune system to immediately recognize and destroy viruses with matching protein markers on the surface. The HIV virus is able to constantly change its markers, and thus is nearly impossible to develop a vaccine for.
 
#10 ·
Awesome stuff
 
#13 ·
Good news is good. No sound to watch video at work..
 
#14 ·
Quote:
Originally Posted by Vlasov_581 View Post

so this is a genetically engineered HIV virus, meaning that it doesn't have the code in its DNA to act like the dangerous and fatal version of it like the one that we face in the world?
did you watch the video at all?
 
#15 ·
Why couldnt we have this a few years ago. My dad would definitaly benifit from this right now. Now we just need something that can cure esophagal cancer, spine cancer,lung cancer, and liver cancer all at once like what my dad has.
 
#16 ·
For people w/o sound or haven't watched the video:

HIV primarily targets T-cells.
The labs in this video withdrew blood from the patient, and isolated T cells (not sure which type).
HIV/Lentivirus envelope was produced, and filled with a RT, and specific DNA sequences.
HIV/Lentivirus was incubated with isolated T cells from the patient, thereby infecting the T cells.
T cells spun back down & re-suspended in saline prior to re-introduction to the patient.

Probably stripped out all DNA sequences regarding structural proteins, regulatory elements, and accessory protein sequences leaving behind the HIV envelope only.

No direct targeting of cancer cells here - would require switching gp120 with another marker, a high dose, and would most likely be a one shot vaccine due to immune system adaptability.
 
#19 ·
That is very cool. As said, we know how to stave off the HIV virus MUCH beter than we know how to handle certain cancers.
Also have better advances in that arena for cures, so this could be really big someday.
 
#20 ·
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Originally Posted by robE View Post

Very impressive and touching. Emma will have those modified T-Cells all the life? so basically she will never make leukemia again?
If those T-cells are able to function as normal T-cells and make memory T-cells, then yes, she would have them for the rest of her life. However, whether or not she gets leukemia again depends on whether or not the leukemia shows up with the same markers. If it's with the same markers, it'll be destroyed instantly, but if it's with different ones, those T-cells won't be able to recognize them, since they are very specific to what they attack.
 
#22 ·
Quote:
Originally Posted by robE View Post

Very impressive and touching. Emma will have those modified T-Cells all the life? so basically she will never make leukemia again?
Unlikely. Other papers published in Cell Stem Cell indicate that these modified T cells become exhausted after a while due to constant exposure to the antigens they are targeted against. Think of it as a soldier on constant duty, with no downtime.
 
#24 ·
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Originally Posted by Moustache View Post

Amazing stuff. Can't wait to share this news with my friend.
This, I am soooo amazed by this. I am absolutely BLOWN AWAY!!!!

Imagine being a parent of that child or being the child itself. That is a miracle. I am just completely blown away. Just wow.

Lets hope this will be available to the masses soon.

And then a cure for MS to cure my father
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#25 ·
Quote:
Originally Posted by Usario View Post

There are no photos of individual atoms, and it wasn't even a month ago that the first photo of a molecule surfaced.

And there are photos of HIV, as another poster already showed.

I know you try to fight against the lies of the government and huge corporations, but perhaps you should check your own sources as well. The theories of HIV being man-made have real credibility; denying HIV's existence is just insane.
Actually, hydrogen, the smallest, hardest to see atom has been pictured.

http://www.foxnews.com/science/2013/05/28/amazing-first-ever-photograph-inside-hydrogen-atom/
 
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