I'm sort of ranting here, but just to put it out there:
Not to knock the project , I like SIMAP but it seems to me Rosetta@Home is a more scientifically valid project (and U of Washington is held in much higher regard worldwide , Rosetta@Home projects has actual publications). SIMAP is more of a cataloging project and the work units tend to thin out towards the end of the month
, so it's a good BGB project but not really a good project of the month. I think Rosetta@Home has more users as well (allprojectstats lists it as an order of magnitude larger ~366K Rosetta users vs 44K for SIMAP); its research is valid enough to have a WCG project stem off it.
SIMAP publications http://boinc.bio.wzw.tum.de/boincsimap/relatedprojects.php
Rosetta@Home publications http://boinc.bakerlab.org/rosetta/rah_publications.php
SIMAP is a database of protein similarities and protein domains. It contains about all currently published protein sequences and is continuously updated. Protein similarities are computed using the FASTA algorithm which provides optimal speed and sensitivity. Protein domains are calculated using the InterPro methods and databases. SIMAP is to our knowledge the only project that combines comprehensive coverage with respect to all known proteins and incremental update capabilities.
BOINCSIMAP is a periodic project that usually has work for a few days at the beginning of each month. The status of the project and the schedule of upcoming work are displayed on the main BOINCSIMAP web page. New work is announced in the project news approximately 24 hours before start.
I'm not a fan of Docking either, since its goal is to develop pharmaceutical drugs it seems more of a for-profit project for big-pharma disguised as disease research.
Rosetta also implements research through experimentation:
Rosetta was shown repeatedly to be one of the best methods for predicting the three-dimensional structures of proteins in the Critical Assessment of Techniques for Protein Structure Prediction (CASP), and has also been successful in CAPRI, the Critical Assessment of Prediction of Interactions.
Our design methods also have shown to produce accurate results. Particularly exciting recently is the creation of novel proteins with arbitrarily chosen three-dimensional structures.
Therefore unlike POEM@Home /GPUGrid , which have a GPU usage option, I think Rosetta is a better CPU-only project. A more superficial reason is it has a nice Folding@Home like "screensaver" too
.BOINC page's recommendations:
In deciding whether to participate in a project, read its web site and consider the following questions:
- Does the project clearly describe its goals? Are these goals important and beneficial?
- Has the project published results in peer-reviewed journals or conferences? See A list of scientific publications of BOINC projects.
- Do you trust the project to use proper security practices?
- Who owns the results of the computation? Will they be freely available? Will they belong to a company?
* Does the project have a goal that is realistically attainable? "Curing XYZ disease" is vague. "Finding out how proteins fold using XYZ method ( CHARMM / FASTA/etc)" , along with the papers and research on your page, is a lot more specific and credible
* Does the project have meaning (to me)? I don't want to waste electricity on prime numbers or collatz , I did that enough when using Prime95
* Do they verify theory or just spit theory out?
* Is the university or foundation (or whoever backs the project) held in high regard in the scientific community?
* Is it non-profit or am I filling someone's coffers in a pseudo "innocuous" bot-net because they are too stingy to buy a proper cluster of servers
* How consistent are work units?
* Do work units crash?
* How long do work units take (Cosmology is terrible in that it has 11+hour WUs like Folding@Home so any memory corruption due to pushing memory clock ; lack of checkpointing really stops progress if anything goes wrong)
* How big are work units? Big work units take up space on my SSD...Disclaimer: this is only my opinion. My apologies in advance if it seems like I'm being harsh.
It's not so much as picking projects. Having a recommended project of the month
that isn't really good for that duration when many are crunching is a problem. Like I stated, it's a good beginning of the month BGB project.
:hattip at the Rosetta progress , however.Edited by AlphaC - 10/21/13 at 3:03pm