I'm sure it would fit depending on your case size and motherboard layout.... that's really where the issues of space would come into play. The largest issue I had was having enough fan headers. Each kraken get set up is going to need 3 fan connections (vram fan, pump and radiator fan). I have my rads set up in push pull so I need 4 per video card plus I had 3 other case fans to plug in (12 fans with the cpu)... ended up getting the NZXT Grid fan controller (between $10-30 depending on retailer) and mounting it in the psu side of my case. In the pic it's in the upper left.