Originally Posted by mdocod
If the bad behavior is repeatable while using alternative drives for system drives, then it's not a drive. If you can narrow it down to occurring with one particular drive used as the system drive then you have your culprit.
In my experience, among "active" components of a computer, storage has the highest failure rate of any component overall, only to be outdone in failure rate by really cheap PSUs (you know, those $14 jobs). Excluding junker PSUs, storage (mechanical and SSD) continues to be the least reliable part of a computer. (coincidentally, it's also the part that most negatively effects us on failure).
Motherboards, GPUs, PSUs, and RAM all fall into a middle ground of reliability. Reliability varies by quality of the specific parts chosen.
On the far end of the spectrum, CPUs have the lowest failure rates and most stringent QA process among active components in a computer. It's the last part to replace when troubleshooting a problem as it is the least likely to be the problem.
He wasn't trying different drives as system drives. He was just booting into Windows on his SSD with one of his hard drives connected, one at a time - rebooting about 5 times each. Then, after doing one at a time, he connected all of them and tried again, rebooting about 5 times.
He said that he gets the boot error about once every other bootup or so.