Their are a few things Asus could do to really entice people to shell out the extra cash for a refresh. I upgraded my USB 3.0 version to the USB 3.1 version just because I thought That was a big enough improvement. in hindsight it was not. Probably because developers have been slow to adopt the standard so I have not seen any usable benefit for my needs. Plenty of USB C devices, but not very many that conform to the USB 3.1 standard. This motherboard is a flagship product so they would get my attention, and money, if they added features that would benefit usability. I don't care about headers for LED lighting or flashy gimmicks. I would like to see them add onboard Thunderbolt 3. Or maybe a second M.2 slot. Preferably vertical mounting. Another issue I ran into, was the inability to plug my three monitors USB hubs, and my Lexar Professional Workflow with 4 modules into the USB ports because of the limitations of the chipset. I never thought I would see those USB limitations in a workstation board. Regardless if I had to choose one major improvement for a refresh, then my vote would be for onboard Thunderbolt 3.
Also, I would like to add that I found plenty of sites that have listed Asus's refresh of their X99 lineup but no mention of a workstation refresh.
One more thing. In regards to the replacement board that Asus sent me for the one that I RMA'd, I contacted Asus yesterday and was informed that the new board they sent me was indeed brand new and not refurbished. The board falls under the server warranty policy which states in part
During the Limited Warranty Period, Asus will, at its sole discretion, repair or replace any defective component.