I have Gigabyte Z87X-D3H. But actually my new Strix Claw mouse is not connected to my case (Fractal Define R4) front panel, but is connected to USB 3.0 hub on my Dell monitor. Whole yesterday I did not have mouse sensor interupt yet. Lets see if it will continue for today....
Before I had Gigabyte M8000X (Avago 9500) connected directly to my case front panel and I had no problem with it.
My Strix Claw is directly connected to the back of the Case right into the PS/2 - usb 2.0 section, like all of my mouse connections. I use to rely on the DELL monitor usb connection until flaky things started to happen.
That would be your problem right there relying on a 3rd party USB hub to transfer signals to your motherboard, some input devices start reacting badly to this. Some very basic mice will work regardless but the more complicated models sometimes cause problems going from USB 3.0 to USB 2.0. I never liked plugging through USB 3.0 connectors when using any mouse, always use USB 2.0.