Put it off, raise the mouse up so the bug activates and then compensate by lowering the sensitivity in-game. It should only get fixed if you change the CPI from the mouse buttons. Just disable those from the software. I don't know how viable this is but when I tested it, the changed CPI was at least consistent.
Out of curiosity, why does your wrist start hurting with it on? Off has the highest lift-off distance for me. Kind of counter-intuitive that lifting the mouse less would be worse.