Originally Posted by MDalton10
But how do you overclock it?
"Fructose transport across cell membranes is carried out by members of the facilitated glucose transporter (GLUT, SLC2) family. Among the 14 members of human GLUT protein family, only GLUT5 is fructose specific and lacks the ability to transport other carbohydrates such as glucose and galactose5,6,7. GLUT5 is expressed in intestinal epithelia, sperm, brain, fat, skeletal muscle and kidney cells8.
Given the medical importance of GLUT5, its inhibitors could potentially serve as therapeutics for the treatment and management of cancer or diabetes. Nonetheless, selective and potent inhibitors for GLUT5 have not been described. Despite the high sequence similarity among GLUT members, known inhibitors of other GLUT proteins (for example cytochalasin B, phloretin, or forskolin) do not affect GLUT5, suggesting that subtle differences may be responsible for ligand specificity among GLUT family members (this work,17,18). Indeed, a recent study found two natural products that inhibit GLUT5; one of which, rubusoside, a natural sweetener from the Chinese sweet tea plant (Rubus suavissimus), inhibited both GLUT1 and GLUT5, the first example of a common inhibitor for these two GLUTs. The other molecule, astragalin-6-glucoside, a flavonoid compound from the American pokeweed (Phytolacca americana) did not affect GLUT1. These inhibitors, though not potent (IC50 values ~ 5 mM) allowed for the identification of active site differences between GLUT1 and GLUT5 responsible for ligand specificity17." https://www.nature.com/articles/srep24240