I can definitely be done. Do you want the screen to still work? , or would you put in a piece of acrylic? (note how the screen isn't flat, acrylic is going to be tricky)
Just have the hoses running through the back of the comp.
One thing I see is that there aren't really enough vents for fans... Make sure you can fit a rad in there before you buy all of your parts.
the screen would be replaced with the 4 intake fans and mesh covering them