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I have heard there are some problems with Mass Effect in Vista from others (not just here) and this may or may not help though I thought it could use a post:

Here are two options I know of that could potentially fix the game so it works, first the easier way:

1. Try running it as administrator ONCE directly through the Program Files directory.

If that does not work.

2. Disable the UAC (User account control) ONCE and then run the game. I have heard UAC currently interferes with the Mass Effect game and this could be a good fix. BASICALLY: Disable the UAC once, run the game once and then switch it back ON.

Hope this helps.

Note: This is for Vista.
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Adventure
(13 items)
 
  
CPUMotherboardGraphicsRAM
AMD FX 8120 Asrock 970 Extreme 3 Cheap 5000 series 16gb 4x4 ddr3 1600 
Hard DriveOptical DriveOSMonitor
350gb SSD Sata III Samsung 22x DVD-RW Windows 7 Home Premium 64bit Asus Pro Art Monitor 23" 
KeyboardPowerCaseMouse
Logitech Standard Xigmatek 750w Modular NZXT Logitech MX530 Gray 
Mouse Pad
Standard 
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Reply