Probably? I can't tell you since there are too many variables... ambient, CFM, direction, ect. It just needs some force airflow.
We will see if it moves enough air. It has two fans: inner fan blows air and can be adjusted to point anywhere, outer fan is an exhaust and speed adjustable. The outer one I plan to run at lowest setting.
For me, my mobo is pretty empty below the lower pcie x16 slot and I have two empty PCI slots below that. So, I should have enough space to move air around in that area. We will see!