Yes as a matter of fact there is all kinds of issues... This mobo is/was made for am2 and coinsidentally can run some am2+ cpu's but the factory HT speed is 1000 w/a system buss of 2000/1600 what ever that means. I think they double the 1000 if you are running a x2 duel core but honestly I'm really not sure on that or what it means (2000/1600) ???
Hope that helps