Oh yes, plenty of people have run overclocks for years with no problems. Heat like I said, is the killer of electronics usually, or they just fail no matter what you do, it's the nature of the beast. Also, upping voltage like already mentioned can be a facter as well, but just upping it a little (as long as your temps are good) won't necessarily harm it whatsoever. For a prescott like yours, recommended safe voltages, are the stock 1.4, up to 1.525. Only a bit higher if you have some extreme cooling setup. And if your temps are good, running it at 1.525 isn't likely to harm it at all. But find the lowest voltage you can run your oc stable with, cause of course lower is better and less stressful on the cpu. People who usually kill their cpu's from overclock are probably either not monitoring their temps, or they're trying to reach some pretty damn extreme oc's. Or their cpu was goind to die anyway, cause it just happens sometimes, luck of the draw.
Read up about it using the search function and you'll see it's true, oc'ing is not a bad thing if you do it correctly. Plus, these cpu's have some pretty good built in thermal protections, it's actually pretty hard to kill one, they're tough little bastards really
. Once they reach a certain temp (over 65 into the 70's or so for prescott), they'll start to throttle themselves to cool off anyway. And if it gets real
hot (I think like 90 something, not sure exactly), it will shut down in order to save itself. I've seen some stress tests done by people way
above recommended temps, and the cpu was fine after. Just stay below 65C under 100% load for a prescott to be safe. I like to keep mine under 60, but that's a personal preference thing. Some like to keep it 55 and lower, but I've seen them stressed to hell running in the upper 80's and over 90, and they don't die.