That's a pretty snazzy upgrade. I'm sure you're going to see some big improvements. I noticed a huge difference in MW2 and Crysis. I didn't get a chance to play Metro 2033 with my old card, but I'm sure it would have brought the GTS to its knees. Hopefully these 465s will unlock and I can actually play Metro without the huge lag in some scenes.
Has your 465 shipped yet?