I've had something similar before, where I could pass a long stress test, only to freeze when starting a small program like office. It turns out that I needed more VTT than I originally thought. I bumped VTT to about 1.35 and it went away! After some testing, I found that 1.345 is about the lowest I can go on VTT without the freezing when running above 4.1GHz. I haven't had a random freeze since!
Do you mind saying what you run (the Multiplyer you use---V-core and vtt for your 4114 Mhz clock)? Maybe I can run faster and still be stable with better settings?