Originally Posted by The Master Chief
Its all about personal preference... Try some different settings see what you like.
+1. The only way you can get a gaming mouse to work like a gaming mouse is to explore the mouse yourself. Play around with the settings and game and see what works best for you. I personally do a combination of settings in the control panel and in-game settings.
For example, I found out only a couple months ago that I'm a low-sensitivity gamer, so all of my in-game and control panel sensitivity settings are pretty low. However, I started out as a medium to high sensitivity gamer...it took time to adjust after realizing I wasn't doing well at these higher sensitivities. Again, it's all about adjusting to the mouse and the way you game.