Sure, the fan holes for the top 120 is going to look a bit funky but it is a trade off, you also loose your cd-rom bay.
You mount it using a Phobya 360mm radgrill and there should be plenty of room for your mobo. You could move the rad closer to the door if needed since in this pic it's centered.
Overall a good method of keeping crossfired 6970's in check on a mATX board.
Still debating on my build...