I went through a few revisions, but finally decided on the below:
1.2x D5B (as I already had one..figured a 2nd one wouldn't hurt) mounted in an EK dual serial top.
2.Dual RS240 radiators mounted on case sides, flowing from outside in, with water split between them in and out. Panaflo high RPM fans outside pushing, Scythe 1900 rpm fans pulling inside, ejecting out the back top of the case.
3. EK Supreme HF plate 1 on CPU, split off to VRM and chipset blocks (Enzotech WMST-88 and DD MCP Universal)
4. Y'd back together, flowing into 120 Swiftech radiator
5. EK 6970 copper/acetal block
6. Y line (T would not fit) back into the inlet of the pump.
Running 1/2" ID silicone tubing, DD/Bitspower "Fatboy" fittings, enzotech "30" angled rotary fittings where needed. I had a helluva time bleeding it through a Swiftech Microres, even one pump was too much, so it was slowed down a lot.
CPU load is 34C with Prime95 Torture Test. GPU is 36C with Kombustor DX11 1080P resolution. Chipset reads 38C under Prime, so I'll likely need to seat the block a little more there. I have not set up the Panaflo fans yet, due to lack of time, so readings were all with 120x25mm fans, 5 in all (1 per radiator). Ambient was 71F in the room at the time. Not the greatest so far, but not a bad start, I think.
For noise, it's pretty much silent aside from the pump noise, which is by no means annoying.