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[PO] The lock shapes the key: Mystery about recognition of unfolded proteins solved

post #1 of 11
Thread Starter 
Quote:
Proteins normally recognize each other by their specific 3-D structure. If the key fits in the lock, a reaction can take place. However there are reactions at the onset of which the key does not really have a shape. German chemists at the Technische Universitaet Muenchen and the Max Planck Research Unit for Enzymology of Protein Folding (Halle/Saale) have now shown how this might work. Their results will appear in PNAS this week.
Quote:
Scientists led by Professor Thomas Kiefhaber (TUM) posed the question of whether local properties are sufficient for the recognition to take place or whether the unstructured binding partner first had to assume a specific spatial structure. Possible candidates were regularly structural elements such as coiled α-helices or β-pleated sheets, in which internal hydrogen bonds are formed.

In collaboration with Professor Gunter Fischer's research group at the Max Planck Research Unit for Enzymology of Protein Folding Halle/Saale, the scientists developed a novel method for observing the formation of individual hydrogen bonds in the course of a binding process.
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post #2 of 11
Very interesting.

More food for F@H?
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post #3 of 11
I'll forward this to my wife. She's currently going through Adv.Cell Molec, immunology and a few other classes. So Generally, all I hear is things about this kind of stuff. She's definitely big on it.
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post #4 of 11
Quote:
Originally Posted by Biscuits_N_Gravy View Post
I'll forward this to my wife. She's currently going through Adv.Cell Molec, immunology and a few other classes. So Generally, all I hear is things about this kind of stuff. She's definitely big on it.
I usually send my girlfriend papers and links after I read them, then ask if I got the jist right =p
    
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post #5 of 11
I remember my biology teacher banging on about how the lock and key model is outdated and we use the induced fit now.

Not that it matters.
post #6 of 11
Quote:
Originally Posted by MrDeodorant View Post
Their results will appear in PNAS this week.
I lol'd
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post #7 of 11
Stanford: "Oh... Well... crap... Guess we can throw all that folding data away"

Hehe, jk.
 
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post #8 of 11
Thread Starter 
I wondered about that, but as I understand it (not being a folder myself, you understand), folding is about how a single protein fits itself together, and this is how two proteins interact with each other. Totally different.
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post #9 of 11
Quote:
Originally Posted by MrDeodorant View Post
I wondered about that, but as I understand it (not being a folder myself, you understand), folding is about how a single protein fits itself together, and this is how two proteins interact with each other. Totally different.
To be honest, I have no clue what they do with the data or what data you crunch while folding. I just like to look at pretty numbers! Well, that and when friends are over, I can boot it up and display the 3d view so they are all "what the... this guy is building people with his computer..."
 
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post #10 of 11
Quote:
Originally Posted by F3AR View Post
I remember my biology teacher banging on about how the lock and key model is outdated and we use the induced fit now.

Not that it matters.
Wake up everybody. It's the 21st century .

Off Topic - you stole my avatar .
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