Did a bit of rearranging. I found that my second setup (Which I mostly use for watching movies and shows) was too far to the right so I would be constantly pivoting from my main system (or my laptop) to the right.
Got some extension cables (long HDMI cable and speaker extension wire) and moved the monitor and 2.1 speakers into the corner. Pushed the printer to one end.
I also grabbed an inexpensive wireless keyboard and mouse in place of my wired set. I don't game with the media rig and only do the most basic typing so it was easier (and less wires). Also allows me to put the kbd and mouse out of the way when not in use for more desk space.
I was thinking of getting another small monitor and putting it where the media one was prior and then wall mounting the 23" Samsung up in the corner but I got lazy....
Still have to clean up the wires a bit under my main system (although they are so far back, its kind of moot).