Some games ti would work, as long as I'm not using a key that the game is using like Skyrim. Other games like Civ5 just won't work period. Like I said, it's fine if you can't do this. I don't mind using Alt+Tab to swap songs. The main reason why I hated doing that was my Skyrim crashed a lot. I now have my modpack stable, so that's not an issue anymore.
And I'm not sure if it would be easier about the key press, but you could make it press a button on a controller. I have a X360 controller that I can remap the buttons for.
Sig's kind of broke a little. It's okay, I needed to update it anyway XD